by Marion Nestle

Currently browsing posts about: Artificial-sweeteners

Oct 2 2011

What to do about food chemicals eaten in tiny amounts?

My once-a-month, first Sunday Food Matters column in the San Francisco Chronicle is about the difficulty of figuring out the health effects of food chemicals consumed in low doses.

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Taking steps on food chemicals

Editor’s note: Nutrition and public policy expert Marion Nestle answers readers’ questions in this monthly column written exclusively for The Chronicle. E-mail your questions to food@sfchronicle.com, with “Marion Nestle” in the subject line.

Q: I don’t understand why the FDA does not ban aspartame, food colors, BPA, pesticides and all those other nasty chemicals in food. I can’t believe they are good for us.

A: I can’t, either. But the Food and Drug Administration is required to make decisions on the basis of science, not beliefs.

You eat these chemicals in tiny amounts – parts per billion or trillion. Whether doses this low cause harm is hard to assess for two reasons: science and politics. Scientists cannot easily measure the health effects of exposure to low-dose chemicals. And the industries that make and use these chemicals don’t want to give them up.

Food chemicals elicit plenty of public dread and outrage. But are they harmful?

Controlled clinical trials at normal levels of intake would require vast numbers of subjects over decades. Nobody would fund them.

Instead, researchers use animals consuming much higher doses. I can remember how the diet soda industry ridiculed studies suggesting that saccharine caused bladder cancer in rats: the doses were equivalent to drinking 1,250 12-ounce diet sodas a day.

The difficulties of doing research on low-dose chemicals – and the food industry’s insistence that such doses are safe – explains the FDA’s reluctance to act.

Some examples illustrate the problem.

Aspartame

Some studies suggest that aspartame might cause cancer in rats when consumed at levels typical of diet soft drinks, as well as other problems. But researchers performing better controlled studies have given aspartame a clean bill of health.

Despite public concerns, the FDA’s assessment of the evidence “finds no reason to alter its previous conclusion that aspartame is safe as a general purpose sweetener in food.”

Food dyes

These have been considered a possible cause of hyperactivity in children since the 1970s. Some studies show improved behavior among children placed on additive-free diets. But behavior is difficult to judge objectively, and even controlled studies gave mixed results.

A recent study funded by the British Food Standards Agency is typical. It found most children to be unaffected by removing additives. But a small percentage seemed to get better.

The FDA can only conclude that there is not enough science to decide whether food dyes cause hyperactivity.

BPA (Bisphenol A)

BPA is a component of hard plastic used to make baby bottles and food and beverage cans. It is also an endocrine disrupter. Last year, the FDA concluded that BPA is safe at current exposure levels.

At the same time, the FDA advised children and pregnant women to reduce exposure to BPA. It advised the infant formula and soda industries to find ways to replace it.

The California Legislature has passed AB1319 banning BPA from baby bottles and sippy cups; it’s awaiting Gov. Jerry Brown’s signature.

Recent studies raise concerns about BPA’s effects on the brain and behavior of fetuses, infants and young children, and on cancer, obesity and infertility in adults. Some studies suggest that exposure to BPA is higher than previously estimated. Just last week, the Breast Cancer Fund released a study finding BPA in canned foods designed for children.

Studies by university scientists tend to find harm from BPA at low doses, whereas those by government regulatory agencies and the food industry do not. In the absence of compelling science, regulators have two choices: exercise the “precautionary principle” and ban the chemical until it can be proven safe, or approve it until it can be shown to be harmful.

The United States and European safety agencies – and the food industry, of course – prefer the latter approach.

Pesticides

Research clearly demonstrates that pesticides harm farmworkers exposed to high doses. But recent studies report slightly lower IQ levels in children born to urban women with higher blood levels of pesticides. Although these studies did not control for socioeconomic and other variables that might influence IQ, they raise the possibility that even low levels might be harmful.

What to do?

While waiting for the science to evolve, you can take both personal and political action.

You don’t want potentially harmful chemicals in your foods? Read labels and don’t buy foods with artificial sweeteners or food colors. Kids don’t need them anyway.

Consumer action has already induced baby bottle makers to get rid of BPA. This strategy can work for food colors, too.

Don’t stop eating fruits and vegetables. Their known health benefits greatly outweigh the potential harm of pesticides. Don’t stop eating them.

Buy organic. Pesticides, invisible and unlabeled as they are, constitute a good reason to do so.

Get political. Let your congressional representatives know that more research is needed, but you don’t want to wait for it. You want industry to find healthier alternatives.

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Marion Nestle is the author of “Food Politics” and “What to Eat,” among other books, and is a professor in the nutrition, food studies and public health department at New York University. E-mail comments to food@sfchronicle.com.

This article appeared on page G – 10 of the San Francisco Chronicle

 

Feb 10 2011

Do diet sodas really cause stroke? I’m dubious.

I’ve been asked repeatedly this week to comment on the huge press outcry about a study that links diet sodas to an increased risk of stroke and heart disease.

I have not seen the study and neither has anyone else. It is not yet published.

It was presented at the American Stroke Association’s International Stroke Conference 2011.  The American Heart Association has a short summary on its website.  And Rosie Mestel has an excellent account in the Los Angeles Times.

Here’s what I can glean from the limited information available:

  • The study started in 2003.  It was designed to determine risk factors for heart disease and stroke in a multi-ethnic New York City population.
  • It used a food frequency questionnaire to ask about 2,500 people how often they drank diet sodas (among many other questions).
  • Nine years later, it assessed rates of stroke and heart disease.
  • The result: people who said they habitually drank diet sodas had a 60% higher rate of stroke and heart attacks.
  • They had a 48% higher rate when the data were controlled for contributing factors: age, sex, race, smoking, exercise, alcohol, daily calories, and metabolic syndrome.

That is all we know.

Does this study really mean that “diet soda may not be the optimal substitute for sugar-sweetened beverages for protection against vascular outcomes,” as the lead author is quoted as saying?

As Rosie Mestel puts it:

It’s worth noting, as some scientists did, that this is a link, not proof of cause and effect. After all, there are many things that people who slurp diet sodas every day are apt to do – like eat a lousy diet — and not all of these can be adjusted for, no matter how hard researchers try. Maybe those other factors are responsible for the stroke and heart attack risk, not the diet drinks. (Those who drink daily soda of any stripe, diet or otherwise, are probably not the most healthful among us.)

Leaving questions about the accuracy of dietary information obtained by questionnaire, the study raises more important questions:

  1. Could this finding simply be a statistical result of a “fishing expedition?”  The food frequency questionnaire undoubtedly asked hundreds of questions about diet and other matters.  Just by chance, some of them are going to give results that look meaningful.  The increase in stroke risk seems astonishingly high and that also suggests a need for skepticism.
  2. What is the mechanism by which diet sodas lead to stroke or heart disease?  I can’t think of any particular reason why they would unless they are a marker for some known risk factor for those conditions.

Please understand that I am no fan of diet sodas.  I don’t like the metallic taste of artificial sweeteners and they are excluded by  my “don’t eat” rule: never eat anything artificial.

But before I believe that this study means that artificial sweeteners cause cardiovascular problems, I want to see a study designed to test this particular hypothesis and a plausible biological reason for how diet sodas might cause such problems.

Oct 16 2010

Obesity research in action: recent studies

FoodNavigator.com has a special issue on obesity research.  Its reports are based on single studies that may or may not agree with previous research and, therefore, require some interpretation.

Zero-calorie sweeteners do not prompt overeating, finds study: People do not compensate with extra calories after consuming foods and drinks sweetened with zero-calorie sweeteners, suggests a new study published in the journal Appetite…

Fruit flies help explain why diet success varies: A study on fruit flies has indicated that genetic interaction with diet has a greater impact on body weight than diet alone, which the researchers say can help explain different reactions to similar diets….

Sucralose does not promote weight gain: Human study: Consumption of sucralose and sucralose-sweetened products does not affect gut hormones linked to hunger, or detrimentally affect blood sugar levels, says a new study from Australia….

Food addiction: Fat may rewire brain like hard drugs: Overeating may be driven by a same neurobiological mechanism in the brain as drug addition, says a new study from the US that adds clout to the theory ‘food addiction’….

Overeating drives fat gain at the hips, says obesity-related study: Fat tissues in the upper and lower body may gain weight differently, says a new study which deepens our understanding of fat accumulation and obesity….

Two of these studies are about the effects of artificial sweeteners on hunger, satiety, calorie intake, and weight gain.  In contrast to previous studies, both of these find that sweeteners do not cause people to eat more to compensate for the reduced calories.

I’m guessing we will be hearing more about this topic, as new research results come in.  Stay tuned.

Jun 3 2010

Is aspartame “nasty”?

Oh those British libel laws.   According to FoodNavigator.com, a judge in Britain has just ruled that Asda, a grocery company in the UK, may not legally describe aspartame, the artificial sweetener, as “nasty.”

This decision is a reversal of a previous High Court ruling that “nasty” has only a vague meeting and does not constitute “malicious falsehood.”  The Court of Appeals reversed that ruling.

A spokeswoman for the maker of aspartame, Ajinomoto, said:Asda can no longer deny that describing aspartame as a ‘nasty’ denigrates a safe and beneficial food ingredient.” Ajinomoto will now proceed with its malicious falsehood case… We will continue to pursue our case and defend the reputation of aspartame.”

This parsing of the meaning of “nasty” would be deliciously academic if we didn’t have our own veggie libel laws to contend with.

And as FoodNavigator puts it:

The case could have wider implications for firms employing emotive rhetoric about additives in marketing materials, notably Pret A Manger, which last year urged shoppers to “avoid hairy chemicals”, which were defined as “obscure chemicals, additives and preservatives … the nasties we avoid at all costs”.